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Pharmacogenetics Of Vinorelbine In Malignant Pleural Mesothelioma Patients

Condition Malignant Pleural Mesothelioma Estimated Enrollment: 150 Age Group: Child, Adult, Senior Gender: All Study Type: Observational Study Design Allocation: Observational Model: Case-Only|Time Perspective: Retrospective Study ID Numbers: ONC/OSS-02/2012 Study First Received: May 27, 2013 Last Updated: February 9, 2017 Estimated Primary Completion Date: December 2016 Primary Outcome Measures: Expression of TUBB3 and BRCA1 in MPM tumor tissue by immunohistochemistry and RT-PCR.|Association of expression of TUBB3 and BRCA1 with clinical outcome (response, survival) . Sponsors and Collaborators: Armando Santoro, MD|Istituto Clinico Humanitas Result Received: No Study Results Posted Website Link: https://ClinicalTrials.gov/show/NCT01865045...

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Pemetrexed Disodium and Cisplatin With or Without Cediranib Maleate in Treating Patients With Malignant Pleural Mesothelioma

Condition Epithelioid Mesothelioma|Pleural Malignant Mesothelioma|Recurrent Malignant Mesothelioma|Sarcomatoid Mesothelioma Estimated Enrollment: 116 Age Group: 18 Years and older   (Adult, Senior) Gender: All Study Type: Interventional Study Design Allocation: Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Participant, Investigator|Primary Purpose: Treatment Study ID Numbers: NCI-2011-02015|S0905|CDR0000665415|U10CA180888|U10CA032102 Study First Received: February 5, 2010 Last Updated: April 5, 2017 Estimated Primary Completion Date: June 2017 Primary Outcome Measures: Maximum tolerated dose determined if the dose-limiting toxicity rate is less than or equal to 33% according to NCI CTCAE version 4.0 (Phase I)|Progression-free survival (Phase II)|Overall survival (Phase II)|Response (Phase II)|Toxicity assessed using NCI CTCAE version 4.0 (Phase II) Sponsors and Collaborators: National Cancer Institute (NCI) Result Received: No Study Results Posted Website Link:...

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Nivolumab in Patients With Recurrent Malignant Mesothelioma

Condition Malignant Pleural Mesothelioma Estimated Enrollment: 33 Age Group: 18 Years and older   (Adult, Senior) Gender: All Study Type: Interventional Study Design Allocation: Intervention Model: Single Group Assignment|Masking: No masking|Primary Purpose: Treatment Study ID Numbers: N14MPN Study First Received: July 6, 2015 Last Updated: February 27, 2017 Estimated Primary Completion Date: July 2017 Primary Outcome Measures: DCR|PFS|OS|TTP|ORR|Safety and tolerability (The incidence of (serious) adverse events) Sponsors and Collaborators: The Netherlands Cancer Institute|Bristol-Myers Squibb Result Received: No Study Results Posted Website Link: https://ClinicalTrials.gov/show/NCT02497508...

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Nivolumab Monotherapy or Nivolumab Plus Ipilimumab, for Unresectable Malignant Pleural Mesothelioma (MPM) Patients

Condition Mesothelioma Estimated Enrollment: 125 Age Group: 18 Years and older   (Adult, Senior) Gender: All Study Type: Interventional Study Design Allocation: Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Open Label|Primary Purpose: Treatment Study ID Numbers: IFCT-1501 Study First Received: March 9, 2016 Last Updated: October 24, 2016 Estimated Primary Completion Date: May 2017 Primary Outcome Measures: Disease Control rate assessed by CT scan|Number of participants with treatment-related adverse events as assessed by CTCAE v4.0|Progression-Free Survival|Overall Survival|Quality of Life|prognosis impact of blood biomarkers (exploratory studies) Sponsors and Collaborators: Intergroupe Francophone de Cancerologie Thoracique Result Received: No Study Results Posted Website Link: https://ClinicalTrials.gov/show/NCT02716272...

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NGR015: Study in Second Line for Patient With Advanced Malignant Pleural Mesothelioma Pretreated With Pemetrexed

Condition Malignant Pleural Mesothelioma Estimated Enrollment: 390 Age Group: 18 Years and older   (Adult, Senior) Gender: All Study Type: Interventional Study Design Allocation: Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Double Blind (Participant, Care Provider, Investigator, Outcomes Assessor)|Primary Purpose: Treatment Study ID Numbers: NGR015|2009-016879-29 Study First Received: March 17, 2010 Last Updated: October 8, 2015 Estimated Primary Completion Date: December 2016 Primary Outcome Measures: Overall Survival (OS)|Progression-Free Survival (PFS)|Disease Control Rate (DCR)|Duration of Disease Control|Safety and Toxicity according to NCI-CTCAE criteria (version 4.02)|Quality of life (QoL) according to Lung Cancer Symptom Scale|Evaluation of medical care utilization in the two treatment arms Sponsors and Collaborators: MolMed S.p.A. Result Received: No Study Results Posted Website Link: https://ClinicalTrials.gov/show/NCT01098266...

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A Study of BBI608 in Combination With Pemetrexed and Cisplatin in Adult Patients With Malignant Pleural Mesothelioma

Condition Malignant Pleural Mesothelioma|Non-Small Cell Lung Cancer Estimated Enrollment: 24 Age Group: 20 Years and older   (Adult, Senior) Gender: All Study Type: Interventional Study Design Allocation: Intervention Model: Single Group Assignment|Masking: Open Label|Primary Purpose: Treatment Study ID Numbers: D8807005 Study First Received: January 21, 2015 Last Updated: July 19, 2016 Estimated Primary Completion Date: May 2017 Primary Outcome Measures: Phase1: Assessment of safety of BBI608 given in combination with Pemetrexed and Cisplatin by reporting the adverse events and serious adverse events.|Phase1: Assessment of dose-limiting toxicities (DLTs).|Phase1: Pharmacokinetics profile of BBI608 when administered with pemetrexed and cisplatin.|Phase2: Progression Free Survival (PFS)|Phase1: Anti-tumor activity|Phase1: Progression Free Survival(PFS)|Phase1: Overall Survival(OS)|Phase2: Overall Survival (OS)|Phase2: Response...

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Randomized Study of Adjuvant WT-1 Analog Peptide Vaccine in Patients With Malignant Pleural Mesothelioma (MPM) After Completion of Combined Modality Therapy

Condition Malignant Pleural Mesothelioma Estimated Enrollment: 31 Age Group: 18 Years and older   (Adult, Senior) Gender: All Study Type: Interventional Study Design Allocation: Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Double Blind (Participant, Investigator)|Primary Purpose: Treatment Study ID Numbers: 10-134 Study First Received: December 21, 2010 Last Updated: January 4, 2017 Estimated Primary Completion Date: December 2017 Primary Outcome Measures: To assess the 1-year progression free survival in patients|To confirm the immunogenicity of the WT-1 analog peptide vaccine|To assess the utility of using the serum marker|overall survival Sponsors and Collaborators: Memorial Sloan Kettering Cancer Center|United States Department of Defense Result Received: No Study Results Posted Website Link: https://ClinicalTrials.gov/show/NCT01265433...

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Phase II Anetumab Ravtansine as 2nd Line Treatment for Malignant Pleural Mesothelioma (MPM)

Condition Mesothelioma Estimated Enrollment: 248 Age Group: 18 Years and older   (Adult, Senior) Gender: All Study Type: Interventional Study Design Allocation: Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: No masking|Primary Purpose: Treatment Study ID Numbers: 15743|2012-003650-88 Study First Received: November 9, 2015 Last Updated: February 13, 2017 Estimated Primary Completion Date: November 2017 Primary Outcome Measures: Progression Free Survival|Overall survival (OS)|Patient-reported outcomes (PROs)|Objective response rate (ORR)|Duration of response (DOR)|Number of participants with treatment emergent adverse events as a measure of safety and tolerability|Number of participants with serious adverse events as a measure of safety and tolerability|Disease control rate (DCR)|Durable Response Rate (DRR) Sponsors and Collaborators: Bayer|ImmunoGen and MorphoSys Result Received: No Study Results Posted Website Link: https://ClinicalTrials.gov/show/NCT02610140...

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Randomized, Double-blind Study Comparing Tremelimumab to Placebo in Subjects With Unresectable Malignant Mesothelioma

Condition Unresectable Pleural or Peritoneal Malignant Mesothelioma Estimated Enrollment: 658 Age Group: 18 Years to 99 Years   (Adult, Senior) Gender: All Study Type: Interventional Study Design Allocation: Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Participant, Care Provider, Investigator, Outcomes Assessor|Primary Purpose: Treatment Study ID Numbers: D4880C00003 Study First Received: April 22, 2013 Last Updated: January 24, 2017 Estimated Primary Completion Date: January 2016 Primary Outcome Measures: Overall survival (OS) time by treatment arm|Durable disease control rate by treatment arm|Length of progression-free survival by treatment arm|Overall response rate by treatment arm|Duration of response by treatment arm|Number of participants reporting any adverse event|Number of participants with changes in patient-reported outcomes|Number of participants reporting any serious...

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Effect of FAS and FAS Ligand Polymorphisms on Patients With Platinum-Based -Treated Malignant Pleural Mesothelioma

Condition Malignant Pleural Mesothelioma Estimated Enrollment: 60 Age Group: 18 Years and older   (Adult, Senior) Gender: All Study Type: Observational Study Design Allocation: Observational Model: Cohort|Time Perspective: Prospective Study ID Numbers: Master (No14) Study First Received: October 11, 2014 Last Updated: June 8, 2016 Estimated Primary Completion Date: June 2016 Primary Outcome Measures: response rate|progression free survival (PFS)|overall survival (OS)|estimation of treatment related toxicity Sponsors and Collaborators: Ain Shams University Result Received: No Study Results Posted Website Link: https://ClinicalTrials.gov/show/NCT02269878...

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