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25 April
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Triplet Combination First Line Treatment in Non Small Cell Lung Cancer (NSCLC)

Posted by Goldberg, Persky & White P.C.

Condition Metastatic Non-squamous Non Small Cell Lung Cancer Estimated Enrollment: 201 Age Group: 18 Years and older   (Adult, Senior) Gender: All Study Type: Interventional Study Design Allocation: Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Open Label|Primary Purpose: Treatment Study ID Numbers: CBP08-02 Study First Received: July 17, 2009 Last Updated: July 29, 2013 Estimated Primary Completion Date: July 2013 Primary Outcome Measures: The primary efficacy endpoint is Progression free survival, analyzed in the treated population. PFS is assessed from randomization until either tumor progression, as per RECIST criteria, or until death due to any reason.|Objective response rate (CR + PR): response is to be assessed according to RECIST criteria (see Section 7.1), with...

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25 April
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A Study To Find The Best Dose Of SU011248 When Given With Pemetrexed, Pemetrexed And Cisplatin Or Pemetrexed And Carboplatin In Patients With Advanced Solid Tumors

Posted by Goldberg, Persky & White P.C.

Condition Neoplasms Estimated Enrollment: 96 Age Group: 18 Years and older   (Adult, Senior) Gender: All Study Type: Interventional Study Design Allocation: Allocation: Non-Randomized|Intervention Model: Parallel Assignment|Masking: Open Label|Primary Purpose: Treatment Study ID Numbers: A6181084 Study First Received: September 10, 2007 Last Updated: April 7, 2011 Estimated Primary Completion Date: April 2010 Primary Outcome Measures: To determine maximally tolerated dose of SU011248 (dosed continuously or on a 2/1 Schedule) when given in combination with pemetrexed, pemetrexed and cisplatin or pemetrexed and carboplatin.|To evaluate the plasma pharmacokinetics of SU011248 and its metabolite, SU012662 in addition to pemetrexed, SU011248 and pemetrexed/cisplatin, and SU011248 and pemetrexed/carboplatin when these drugs are co-administered.|To preliminarily assess the antitumor...

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25 April
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Alanosine in Treating Patients With Cancer

Posted by Goldberg, Persky & White P.C.

Condition Lung Cancer|Malignant Mesothelioma|Pancreatic Cancer|Sarcoma Estimated Enrollment: null Age Group: 13 Years and older   (Child, Adult, Senior) Gender: All Study Type: Interventional Study Design Allocation: Masking: Open Label|Primary Purpose: Treatment Study ID Numbers: SALMEDIX-SDX-102-01|MSKCC-03029|CDR0000304677 Study First Received: June 5, 2003 Last Updated: June 25, 2013 Estimated Primary Completion Date: December 2005 Primary Outcome Measures: Sponsors and Collaborators: Memorial Sloan Kettering Cancer Center|National Cancer Institute (NCI) Result Received: No Study Results Posted Website Link: https://ClinicalTrials.gov/show/NCT00062283...

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25 April
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Feasibility of an Early Palliative Care Intervention for Metastatic Cancer Patients. A Phase 2 Study.

Posted by Goldberg, Persky & White P.C.

Condition Lung Cancer|Mesothelioma|Pancreas Cancer|Gastric Cancer Estimated Enrollment: 40 Age Group: 18 Years and older   (Adult, Senior) Gender: All Study Type: Interventional Study Design Allocation: Intervention Model: Single Group Assignment|Masking: Open Label|Primary Purpose: Supportive Care Study ID Numbers: CE148/2012 Study First Received: March 1, 2014 Last Updated: July 30, 2015 Estimated Primary Completion Date: April 2014 Primary Outcome Measures: percentage of cancer patients that accept and attend the early palliative care programme|percentage of cancer patients that receive the proposal of early palliative by the oncologists-pneumologists Sponsors and Collaborators: Arcispedale Santa Maria Nuova-IRCCS Result Received: No Study Results Posted Website Link: https://ClinicalTrials.gov/show/NCT02078700...

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25 April
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Phase I Study of Gene Induction Mediated by Sequential Decitabine/Depsipeptide Infusion With or Without Concurrent Celecoxib in Subjects With Pulmonary and Pleural Malignancies

Posted by Goldberg, Persky & White P.C.

Condition Advanced Esophageal Cancers|Primary Small Cell Lung Cancers|Non-Small-Cell Lung Carcinoma|Pleural Mesotheliomas|Cancers of Non-thoracic Origin With Metastases to the Lungs or Pleura Estimated Enrollment: 34 Age Group: 18 Years to 65 Years   (Adult) Gender: All Study Type: Interventional Study Design Allocation: Allocation: Non-Randomized|Intervention Model: Parallel Assignment|Primary Purpose: Treatment Study ID Numbers: 020205|02-C-0205 Study First Received: May 21, 2002 Last Updated: April 19, 2017 Estimated Primary Completion Date: October 8, 2008 Primary Outcome Measures: Pharmacokinetics and toxicity profile Sponsors and Collaborators: National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) Result Received: No Study Results Posted Website Link: https://ClinicalTrials.gov/show/NCT00037817...

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25 April
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Inhaled Doxorubicin in Treating Patients With Advanced Solid Tumors Affecting the Lungs

Posted by Goldberg, Persky & White P.C.

Condition Lung Cancer|Malignant Mesothelioma|Metastatic Cancer Estimated Enrollment: null Age Group: 18 Years and older   (Adult, Senior) Gender: All Study Type: Interventional Study Design Allocation: Primary Purpose: Treatment Study ID Numbers: 000088|00-C-0088|CDR0000067718 Study First Received: July 11, 2001 Last Updated: March 14, 2012 Estimated Primary Completion Date: null Primary Outcome Measures: Sponsors and Collaborators: National Institutes of Health Clinical Center (CC)|National Cancer Institute (NCI) Result Received: No Study Results Posted Website Link: https://ClinicalTrials.gov/show/NCT00020124...

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25 April
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Treatment of Peritoneal Cancer With Surgery, Perfused Heated Cisplatin and Chemotherapy

Posted by Goldberg, Persky & White P.C.

Condition Abdominal Neoplasm|Colonic Neoplasm|Mesothelioma|Peritoneal Neoplasm Estimated Enrollment: 188 Age Group: 18 Years and older   (Adult, Senior) Gender: All Study Type: Interventional Study Design Allocation: Allocation: Non-Randomized|Intervention Model: Parallel Assignment|Masking: Open Label|Primary Purpose: Treatment Study ID Numbers: 000069|00-C-0069 Study First Received: February 3, 2000 Last Updated: October 19, 2015 Estimated Primary Completion Date: August 2009 Primary Outcome Measures: Number of Participants With Disease-free Survival|Number of Participants With a Response|Number of Participants With Adverse Events|Percentage of Participants Who Had Paclitaxel and 5-fluorouracil (5-FU) Analysis Performed|Quality of Life Questionnaire Score|Signal Transduction Pathways in Tumor Tissue Versus Normal Tissue Sponsors and Collaborators: National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) Result Received: August 30, 2011 Website Link:...

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25 April
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A Single-Dose Pilot Study of Radiolabeled Amatuximab (MORAb-009) in Mesothelin Over Expressing Cancers

Posted by Goldberg, Persky & White P.C.

Condition Mesothelioma|Pancreatic Cancer|Ovarian Cancer|Non-small Cell Lung Cancer Estimated Enrollment: 6 Age Group: 18 Years and older   (Adult, Senior) Gender: All Study Type: Interventional Study Design Allocation: Intervention Model: Single Group Assignment|Masking: Open Label|Primary Purpose: Basic Science Study ID Numbers: MORAb-009-006 Study First Received: January 7, 2011 Last Updated: September 28, 2016 Estimated Primary Completion Date: March 2013 Primary Outcome Measures: Primary Objective: determine biodistribution of radiolabeled amatuximab in tumor and nontumor tissue|Secondary objectives: determine the safety of a single IV of Indium-CHX-A amatuximab|Pharmacokinetic and serum levels|uptake of Indium-CHX-A amatuximab|occurrence of HACA|correlate shed serum mesothelin to imaging Sponsors and Collaborators: Morphotek Result Received: No Study Results Posted Website Link: https://ClinicalTrials.gov/show/NCT01521325...

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25 April
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Study of Pemetrexed in Mesothelioma and Lung Cancer Patients With Fluid Around the Lungs or Abdomen

Posted by Goldberg, Persky & White P.C.

Condition Non-small Cell Lung Cancer|Mesothelioma|Lung Neoplasms Estimated Enrollment: 31 Age Group: 18 Years and older   (Adult, Senior) Gender: All Study Type: Interventional Study Design Allocation: Allocation: Non-Randomized|Intervention Model: Single Group Assignment|Masking: Open Label|Primary Purpose: Treatment Study ID Numbers: 10426|H3E-MC-JMHX Study First Received: April 18, 2006 Last Updated: June 10, 2010 Estimated Primary Completion Date: March 2009 Primary Outcome Measures: Overview of Adverse Events|Number of Participants With Common Toxicity Criteria - National Cancer Institute Grade 3 and Grade 4 Toxicities|Pemetrexed Population Pharmacokinetics (PK): Clearance|Pemetrexed Population Pharmacokinetics: Volume of Distribution|Discontinuations Due to Adverse Events Sponsors and Collaborators: Eli Lilly and Company Result Received: March 10, 2010 Website Link: https://ClinicalTrials.gov/show/NCT00316225...

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25 April
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Combination Chemotherapy With or Without Bevacizumab in Treating Patients With Malignant Mesothelioma

Posted by Goldberg, Persky & White P.C.

Condition Advanced Malignant Mesothelioma|Epithelial Mesothelioma|Localized Malignant Mesothelioma|Recurrent Malignant Mesothelioma|Sarcomatous Mesothelioma Estimated Enrollment: 106 Age Group: 18 Years and older   (Adult, Senior) Gender: All Study Type: Interventional Study Design Allocation: Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Double-Blind|Primary Purpose: Treatment Study ID Numbers: NCI-2012-02430|CDR0000069058|NCI-2710|UCCRC-11046A|11046A|2710|N01CM17102|P30CA014599 Study First Received: December 7, 2001 Last Updated: February 10, 2014 Estimated Primary Completion Date: May 2006 Primary Outcome Measures: Time to disease progression|Complete response rate|Objective response rate (complete and partial response)|Rate of disease stabilization|Overall survival|Incidence of adverse events graded according to NCI CTCAE version 3.0 Sponsors and Collaborators: National Cancer Institute (NCI) Result Received: No Study Results Posted Website Link: https://ClinicalTrials.gov/show/NCT00027703...

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