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Standard Chemotherapy With of Without Axitinib in Malignant Mesothelioma

ConditionMalignant Pleural MesotheliomaEstimated Enrollment: 32Age Group: 18 Years and older   (Adult, Senior)Gender: AllStudy Type: InterventionalStudy Design Allocation: Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: No masking|Primary Purpose: TreatmentStudy ID Numbers: NL25655.031.08Study First Received: September 27, 2010Last Updated: February 27, 2017Estimated Primary Completion Date: November 13, 2012Primary Outcome Measures:To test the impact of the addition of axitinib to standaard chemotherapy treatment on histology samples|the side effects of the standard chemotherapy and the additional risks related to axitinib useSponsors and Collaborators:The Netherlands Cancer Institute|PfizerResult Received: No Study Results PostedWebsite Link: https://ClinicalTrials.gov/show/NCT01211275...

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Capecitabine in Treating Patients With Malignant Mesothelioma

ConditionMalignant MesotheliomaEstimated Enrollment: 27Age Group: 18 Years and older   (Adult, Senior)Gender: AllStudy Type: InterventionalStudy Design Allocation: Intervention Model: Single Group Assignment|Masking: Open Label|Primary Purpose: TreatmentStudy ID Numbers: CALGB-39807|U10CA031946|CLB-39807|CDR0000067422Study First Received: January 21, 2000Last Updated: July 12, 2016Estimated Primary Completion Date: December 2003Primary Outcome Measures:Sponsors and Collaborators:Alliance for Clinical Trials in Oncology|National Cancer Institute (NCI)Result Received: No Study Results PostedWebsite Link: https://ClinicalTrials.gov/show/NCT00004183...

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Bortezomib and Cisplatin as First-Line Therapy in Treating Patients With Malignant Mesothelioma

ConditionMalignant MesotheliomaEstimated Enrollment: 82Age Group: 18 Years and older   (Adult, Senior)Gender: AllStudy Type: InterventionalStudy Design Allocation: Intervention Model: Single Group Assignment|Masking: Open Label|Primary Purpose: TreatmentStudy ID Numbers: EORTC-08052|JJPRD-26866138CAN2012|2006-000009-51Study First Received: April 9, 2007Last Updated: April 19, 2013Estimated Primary Completion Date: April 2010Primary Outcome Measures:Progression-free survival (PFS) rate at 18 weeks|Overall objective response rate|Symptomatic response rate|Safety as measured by NCI CTCAE v3.0 and the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity questionnaire|Duration of PFS|Overall survivalSponsors and Collaborators:European Organisation for Research and Treatment of Cancer - EORTCResult Received: No Study Results PostedWebsite Link: https://ClinicalTrials.gov/show/NCT00458913...

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Surgery and Photodynamic Therapy in Treating Patients With Malignant Mesothelioma

ConditionMalignant MesotheliomaEstimated Enrollment: 12Age Group: 18 Years and older   (Adult, Senior)Gender: AllStudy Type: InterventionalStudy Design Allocation: Intervention Model: Single Group Assignment|Masking: Open Label|Primary Purpose: TreatmentStudy ID Numbers: CDR0000269674|RPCI-RP-9812Study First Received: February 5, 2003Last Updated: February 25, 2011Estimated Primary Completion Date: June 2006Primary Outcome Measures:Feasibility|Comparison of results from this regimen to historical controls|Toxic effectsSponsors and Collaborators:Roswell Park Cancer InstituteResult Received: No Study Results PostedWebsite Link: https://ClinicalTrials.gov/show/NCT00054002...

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Study of NGR-hTNF as Single Agent in Patients Affected by Advanced or Metastatic Malignant Pleural Mesothelioma

ConditionMalignant Pleural MesotheliomaEstimated Enrollment: 57Age Group: 18 Years and older   (Adult, Senior)Gender: AllStudy Type: InterventionalStudy Design Allocation: Intervention Model: Single Group Assignment|Masking: Open Label|Primary Purpose: TreatmentStudy ID Numbers: NGR010|EUDRACT Number: 2006-005993-39Study First Received: June 7, 2007Last Updated: October 26, 2015Estimated Primary Completion Date: September 2010Primary Outcome Measures:• Antitumor activity defined as progression free survival (PFS)|• Tumor Growth Control Rate (TGCR) according to RECIST criteria • Overall survival (OS)|• Experimental Imaging Study (DCE-MRI)|• Pharmacokinetics in patients treated with weekly schedule|•SafetySponsors and Collaborators:MolMed S.p.A.Result Received: No Study Results PostedWebsite Link: https://ClinicalTrials.gov/show/NCT00484276...

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S9810: Gemcitabine Plus Cisplatin in Treating Patients With Malignant Mesothelioma of the Pleura That Cannot Be Removed by Surgery

ConditionMalignant MesotheliomaEstimated Enrollment: 57Age Group: 18 Years and older   (Adult, Senior)Gender: AllStudy Type: InterventionalStudy Design Allocation: Intervention Model: Single Group Assignment|Masking: Open Label|Primary Purpose: TreatmentStudy ID Numbers: CDR0000066832|SWOG-S9810|U10CA032102Study First Received: November 1, 1999Last Updated: October 5, 2012Estimated Primary Completion Date: June 2007Primary Outcome Measures:Estimate overall survival|qualitative and quantitative toxicities|confirmed and unconfirmed complete and partial responseSponsors and Collaborators:Southwest Oncology Group|National Cancer Institute (NCI)Result Received: No Study Results PostedWebsite Link: https://ClinicalTrials.gov/show/NCT00003723...

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PTK787/ZK 222584 in Treating Patients With Unresectable Malignant Mesothelioma

ConditionMalignant MesotheliomaEstimated Enrollment: 47Age Group: 18 Years and older   (Adult, Senior)Gender: AllStudy Type: InterventionalStudy Design Allocation: Intervention Model: Single Group Assignment|Masking: Open Label|Primary Purpose: TreatmentStudy ID Numbers: CALGB-30107|U10CA031946|CDR0000269537Study First Received: February 5, 2003Last Updated: June 30, 2016Estimated Primary Completion Date: July 2005Primary Outcome Measures:Survival|Failure free survivalSponsors and Collaborators:Alliance for Clinical Trials in Oncology|National Cancer Institute (NCI)Result Received: No Study Results PostedWebsite Link: https://ClinicalTrials.gov/show/NCT00053885...

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Combination Chemotherapy Before Surgery in Treating Patients With Mesothelioma of the Lung

ConditionMalignant MesotheliomaEstimated Enrollment: 61Age Group: 18 Years and older   (Adult, Senior)Gender: AllStudy Type: InterventionalStudy Design Allocation: Intervention Model: Single Group Assignment|Masking: Open Label|Primary Purpose: TreatmentStudy ID Numbers: SAKK 17/00|SWS-SAKK-17-00|EU-20136Study First Received: February 14, 2002Last Updated: May 14, 2012Estimated Primary Completion Date: May 2003Primary Outcome Measures:Sponsors and Collaborators:Swiss Group for Clinical Cancer ResearchResult Received: No Study Results PostedWebsite Link: https://ClinicalTrials.gov/show/NCT00030745...

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SS1(dsFV)PE38 Plus Pemetrexed and Cisplatin to Treat Malignant Pleural Mesothelioma

ConditionMesotheliomaEstimated Enrollment: 24Age Group: 18 Years to 100 Years   (Adult, Senior)Gender: AllStudy Type: InterventionalStudy Design Allocation: Allocation: Non-Randomized|Intervention Model: Parallel Assignment|Primary Purpose: TreatmentStudy ID Numbers: 080026|08-C-0026Study First Received: September 30, 2011Last Updated: April 20, 2017Estimated Primary Completion Date: January 31, 2014Primary Outcome Measures:Safety and MTD|Best overall responseSponsors and Collaborators:National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC)Result Received: No Study Results PostedWebsite Link: https://ClinicalTrials.gov/show/NCT01445392...

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Cisplatin With or Without Pemetrexed Disodium in Treating Patients With Malignant Mesothelioma of the Pleura That Cannot be Removed by Surgery

ConditionMalignant MesotheliomaEstimated Enrollment: nullAge Group: 18 Years and older   (Adult, Senior)Gender: AllStudy Type: InterventionalStudy Design Allocation: Allocation: Randomized|Primary Purpose: TreatmentStudy ID Numbers: 99-085|CDR0000067791|CWRU-LILY-1599|LILLY-H3E-MC-JMCH(a)|NCI-G00-1767Study First Received: May 2, 2000Last Updated: June 17, 2013Estimated Primary Completion Date: November 2000Primary Outcome Measures:Sponsors and Collaborators:Memorial Sloan Kettering Cancer Center|National Cancer Institute (NCI)Result Received: No Study Results PostedWebsite Link: https://ClinicalTrials.gov/show/NCT00005636...

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