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Safety Study of MGD009 in B7-H3-expressing Tumors

Condition Mesothelioma|Bladder Cancer|Melanoma|Squamous Cell Carcinoma of the Head and Neck|Non Small Cell Lung Cancer|Clear Cell Renal Cell Carcinoma|Ovarian Cancer|Thyroid Cancer|Breast Cancer|Pancreatic Cancer|Prostate Cancer|Colon Cancer|Soft Tissue Sarcoma Estimated Enrollment: 114 Age Group: 18 Years and older   (Adult, Senior) Gender: All Study Type: Interventional Study Design Allocation: Intervention Model: Single Group Assignment|Masking: Open Label|Primary Purpose: Treatment Study ID Numbers: CP-MGD009-01 Study First Received: November 20, 2015 Last Updated: August 10, 2016 Estimated Primary Completion Date: December 2018 Primary Outcome Measures: Number of participants with adverse events|Peak plasma concentration|Number of participants that develop anti-drug antibodies|Change in tumor volume Sponsors and Collaborators: MacroGenics Result Received: No Study Results Posted Website Link: https://ClinicalTrials.gov/show/NCT02628535...

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Tazemetostat Rollover Study (TRuST): An Open-Label Rollover Study

Condition Diffuse Large B-cell Lymphoma|Follicular Lymphoma|Malignant Rhabdoid Tumors (MRT)|Rhabdoid Tumors of the Kidney (RTK)|Atypical Teratoid Rhabdoid Tumors (ATRT)|Synovial Sarcoma|Epitheliod Sarcoma|Mesothelioma|Advanced Solid Tumors Estimated Enrollment: 300 Age Group: 18 Years and older   (Adult, Senior) Gender: All Study Type: Interventional Study Design Allocation: Intervention Model: Single Group Assignment|Masking: Open Label|Primary Purpose: Treatment Study ID Numbers: EZH-501 Study First Received: August 5, 2016 Last Updated: September 13, 2016 Estimated Primary Completion Date: December 2023 Primary Outcome Measures: Long-term safety profile of tazemetostat measured by number of AEs and duration of exposure to tazemetostat|The overall survival (OS) Sponsors and Collaborators: Epizyme, Inc. Result Received: No Study Results Posted Website Link: https://ClinicalTrials.gov/show/NCT02875548...

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CBT-501 Study for Select Advanced or Relapsed/Recurrent Solid Tumors

Condition Solid Tumor|Advanced Cancer|ColoRectal Cancer|Endometrial Cancer|Gastric Cancer|Hepatocellular Cancer|Nonsmall Cell Lung Cancer|Mesothelioma|Ovarian Cancer|Renal Cancer|Nasopharyngeal Cancer|Esophageal Cancer|Gastroesophageal Junction Adenocarcinoma Estimated Enrollment: 50 Age Group: 18 Years and older   (Adult, Senior) Gender: All Study Type: Interventional Study Design Allocation: Intervention Model: Single Group Assignment|Masking: No masking|Primary Purpose: Treatment Study ID Numbers: CBT-501-01 Study First Received: January 30, 2017 Last Updated: March 30, 2017 Estimated Primary Completion Date: February 2018 Primary Outcome Measures: Number of participants with treatment related adverse events as assessed by Common Terminology Criteria for Adverse Events (CTCAE v4.03) in patients with advance solid tumors|Determine the recommended Phase 2 dose and schedule|Area under the plasma concentration versus time curve (AUC)|Maximum plasma concentration|Time...

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Cancer Research Repository for Individuals With Cancer Diagnosis, High Risk Individuals, and Individuals With No History of Cancer (Control)

Condition Pancreatic Cancer|Thyroid Cancer|Lung Cancer|Esophageal Cancer|Thymus Cancer|Colon Cancer|Rectal Cancer|GIST|Anal Cancer|Bile Duct Cancer|Duodenal Cancer|Gallbladder Cancer|Gastric Cancer|Liver Cancer|Small Intestine Cancer|Peritoneal Surface Malignancies|Familial Adenomatous Polyposis|Lynch Syndrome|Bladder Cancer|Kidney Cancer|Penile Cancer|Prostate Cancer|Testicular Cancer|Ureter Cancer|Urethral Cancer|Hypopharyngeal Cancer|Laryngeal Cancer|Lip Cancer|Oral Cavity Cancer|Nasopharyngeal Cancer|Oropharyngeal Cancer|Paranasal Sinus Cancer|Nasal Cavity Cancer|Salivary Gland Cancer|Skin Cancer|CNS Tumor|CNS Cancer|Mesothelioma|Breastcancer|Leukemia|Melanoma|Sarcoma|Unknown Primary Tumor|Multiple Myeloma|Ovarian Cancer|Endometrial Cancer|Vaginal Cancer Estimated Enrollment: 9999 Age Group: 19 Years to 110 Years   (Adult, Senior) Gender: All Study Type: Observational Study Design Allocation: Observational Model: Cohort|Time Perspective: Prospective Study ID Numbers: UNMC 253-13 Study First Received: December 2, 2013 Last Updated: November 14, 2016 Estimated Primary Completion Date: December 2099 Primary Outcome Measures: Development and implementation of a web-based Cancer Collaborative Registry...

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Influence of Psychosocial Distress and Lifetime Trauma Exposure on Traumatic Stress Among Oncology Patients on Clinical Trials

Condition Lymphoma|Thorasic Cancers|Prostate Cancer|Leukemia Estimated Enrollment: 360 Age Group: 18 Years and older   (Adult, Senior) Gender: All Study Type: Observational Study Design Allocation: Observational Model: Case-Control|Time Perspective: Cross-Sectional Study ID Numbers: 170010|17-CC-0010 Study First Received: October 27, 2016 Last Updated: April 21, 2017 Estimated Primary Completion Date: August 28, 2019 Primary Outcome Measures: Traumatic Stress Symptoms Sponsors and Collaborators: National Institutes of Health Clinical Center (CC) Result Received: No Study Results Posted Website Link: https://ClinicalTrials.gov/show/NCT02948413...

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Treatment of Relapsed and/or Chemotherapy Refractory Advanced Malignancies by CART-meso

Condition Malignant Mesothelioma|Pancreatic Cancer|Ovarian Tumor|Triple Negative Breast Cancer|Endometrial Cancer|Other Mesothelin Positive Tumors Estimated Enrollment: 20 Age Group: 18 Years to 70 Years   (Adult, Senior) Gender: All Study Type: Interventional Study Design Allocation: Intervention Model: Single Group Assignment|Masking: Open Label|Primary Purpose: Treatment Study ID Numbers: s2015-080-06 Study First Received: October 19, 2015 Last Updated: October 19, 2015 Estimated Primary Completion Date: November 2017 Primary Outcome Measures: Occurrence of Study related adverse events|Anti-tumor responses to CART-meso cell infusions Sponsors and Collaborators: Chinese PLA General Hospital Result Received: No Study Results Posted Website Link: https://ClinicalTrials.gov/show/NCT02580747...

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An Audit of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy

Condition Colorectal Cancer|Ovarian Cancer|Peritoneal Disease Estimated Enrollment: 150 Age Group: 18 Years to 70 Years   (Adult, Senior) Gender: All Study Type: Observational Study Design Allocation: Observational Model: Cohort|Time Perspective: Prospective Study ID Numbers: PN 1667 Study First Received: March 29, 2016 Last Updated: May 11, 2016 Estimated Primary Completion Date: April 2021 Primary Outcome Measures: Changes in invasive blood pressure in perioperative period|Changes in body temperature in perioperative period|Changes in cardiac output in perioperative period|Changes in arterial blood gas in perioperative period|Length of stay in intensive care unit|Mortality Sponsors and Collaborators: Tata Memorial Centre Result Received: No Study Results Posted Website Link: https://ClinicalTrials.gov/show/NCT02754115...

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Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining

Condition Pulmonary Metastases From Cancers|Mediastinal or Chest Wall Neoplasms|Malignant Pleural Mesotheliomas NOS|Esophageal Cancers NOS|Lung Cancer NOS Estimated Enrollment: 800 Age Group: up to 100 Years   (Child, Adult, Senior) Gender: All Study Type: Observational Study Design Allocation: Observational Model: Case-Only|Time Perspective: Prospective Study ID Numbers: 060014|06-C-0014 Study First Received: October 20, 2005 Last Updated: April 21, 2017 Estimated Primary Completion Date: null Primary Outcome Measures: Permit evaluation of patients referred to the Thoracic Surgery Section, of the Thoracic and GI Malignancies Branch, NCI in order to identify individuals who will be suitable candidates for clinical research protocols|To obtain specimens for research Sponsors and Collaborators: National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) Result...

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Rapid Autopsy and Procurement of Non-Small Cell Lung Cancer Tissue

Condition Thymus Tumors|Mesothelioma|Non- Small Cell Lung Cancer|Small Cell Lung Cancer Estimated Enrollment: 72 Age Group: 18 Years to 100 Years   (Adult, Senior) Gender: All Study Type: Observational Study Design Allocation: Observational Model: Cohort|Time Perspective: Prospective Study ID Numbers: 130131|13-C-0131 Study First Received: May 8, 2013 Last Updated: April 21, 2017 Estimated Primary Completion Date: December 29, 2017 Primary Outcome Measures: Procurement of primary and metastatic tissue of thoracic malignancies shortly after death in order to investigate tumor heterogeneity- both intratumor and between paired primary and metastatic site, using integrated genomic and proteomic analysi...

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Peritoneal Surface Malignancies – Characterization, Models and Treatment Strategies

Condition Pseudomyxoma Peritonei.|Colorectal Carcinoma.|Ovarian Carcinoma.|Mesothelioma. Estimated Enrollment: 200 Age Group: 18 Years and older   (Adult, Senior) Gender: All Study Type: Observational Study Design Allocation: Observational Model: Cohort|Time Perspective: Prospective Study ID Numbers: PSM_250913 Study First Received: February 17, 2014 Last Updated: October 14, 2015 Estimated Primary Completion Date: January 2017 Primary Outcome Measures: Overall survival (OS)|Progression-free survival (PFS) Sponsors and Collaborators: Oslo University Hospital|The Research Council of Norway Result Received: No Study Results Posted Website Link: https://ClinicalTrials.gov/show/NCT02073500...

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