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Pembrolizumab in Treating Patients With Malignant Mesothelioma

ConditionBiphasic Mesothelioma|Epithelioid Mesothelioma|Peritoneal Malignant Mesothelioma|Pleural Biphasic Mesothelioma|Pleural Epithelioid Mesothelioma|Pleural Malignant Mesothelioma|Pleural Sarcomatoid Mesothelioma|Recurrent Peritoneal Malignant Mesothelioma|Recurrent Pleural Malignant Mesothelioma|Sarcomatoid MesotheliomaEstimated Enrollment: 65Age Group: 18 Years and older   (Adult, Senior)Gender: AllStudy Type: InterventionalStudy Design Allocation: Intervention Model: Single Group Assignment|Masking: Open Label|Primary Purpose: TreatmentStudy ID Numbers: IRB14-1381|NCI-2015-00348|P30CA014599Study First Received: March 13, 2015Last Updated: November 14, 2016Estimated Primary Completion Date: March 2018Primary Outcome Measures:Ability of PD-L1 to predict response|Overall survival (OS)|Progression free survival (PFS)|Disease control rate (CR + PR + SD)Sponsors and Collaborators:University of Chicago|National Cancer Institute (NCI)Result Received: No Study Results PostedWebsite Link: https://ClinicalTrials.gov/show/NCT02399371...

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Methoxyamine, Cisplatin, and Pemetrexed Disodium in Treating Patients With Advanced Solid Tumors or Mesothelioma That Cannot Be Removed by Surgery or Mesothelioma That Is Refractory to Pemetrexed Disodium and Cisplatin or Carboplatin

ConditionAdvanced Malignant Solid Neoplasm|Advanced Peritoneal Malignant Mesothelioma|Advanced Pleural Malignant Mesothelioma|Recurrent Malignant Solid Neoplasm|Recurrent Peritoneal Malignant Mesothelioma|Recurrent Pleural Malignant Mesothelioma|Stage III Non-Small Cell Lung Cancer|Stage III Ovarian Cancer|Stage III Pleural Mesothelioma|Stage IIIA Non-Small Cell Lung Cancer|Stage IIIA Ovarian Cancer|Stage IIIB Non-Small Cell Lung Cancer|Stage IIIB Ovarian Cancer|Stage IIIC Ovarian Cancer|Stage IV Non-Small Cell Lung Cancer|Stage IV Ovarian Cancer|Stage IV Pleural Mesothelioma|Thymoma|Unresectable Solid NeoplasmEstimated Enrollment: 58Age Group: 18 Years and older   (Adult, Senior)Gender: AllStudy Type: InterventionalStudy Design Allocation: Allocation: Non-Randomized|Intervention Model: Parallel Assignment|Masking: No masking|Primary Purpose: TreatmentStudy ID Numbers: NCI-2015-00127|PHI-76|9837|P30CA033572|UM1CA186689|UM1CA186705|UM1CA186717|ZIABC011078Study First Received: August 27, 2015Last Updated: March 23, 2017Estimated Primary Completion...

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Genetically Modified T Cells in Treating Patients With Stage III-IV Non-small Cell Lung Cancer or Mesothelioma

ConditionAdvanced Pleural Malignant Mesothelioma|HLA-A*0201 Positive Cells Present|Recurrent Non-Small Cell Lung Carcinoma|Recurrent Pleural Malignant Mesothelioma|Stage III Non-Small Cell Lung Cancer|Stage III Pleural Mesothelioma|Stage IIIA Non-Small Cell Lung Cancer|Stage IIIB Non-Small Cell Lung Cancer|Stage IV Non-Small Cell Lung Cancer|Stage IV Pleural MesotheliomaEstimated Enrollment: 20Age Group: 18 Years and older   (Adult, Senior)Gender: AllStudy Type: InterventionalStudy Design Allocation: Allocation: Non-Randomized|Intervention Model: Parallel Assignment|Masking: Open Label|Primary Purpose: TreatmentStudy ID Numbers: 2727.00|NCI-2015-00329|2727|P30CA015704Study First Received: March 31, 2015Last Updated: January 4, 2017Estimated Primary Completion Date: June 2017Primary Outcome Measures:Evidence and nature of toxicity based on the National Cancer Institute Common Terminology Criteria for Adverse Events version...

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Four Versus Six Cycles of Pemetrexed/Platinum for MPM

ConditionMalignant Pleural MesotheliomaEstimated Enrollment: 70Age Group: 18 Years and older   (Adult, Senior)Gender: AllStudy Type: InterventionalStudy Design Allocation: Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Open Label|Primary Purpose: TreatmentStudy ID Numbers: Meso-01Study First Received: July 10, 2015Last Updated: July 13, 2015Estimated Primary Completion Date: June 2016Primary Outcome Measures:Progression free survival|Overall survivalSponsors and Collaborators:Ain Shams UniversityResult Received: No Study Results PostedWebsite Link: https://ClinicalTrials.gov/show/NCT02497053...

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Short Neoadjuvant Hemithoracic IMRT for MPM

ConditionMalignant Pleural MesotheliomaEstimated Enrollment: 100Age Group: 18 Years and older   (Adult, Senior)Gender: AllStudy Type: InterventionalStudy Design Allocation: Intervention Model: Single Group Assignment|Masking: Open Label|Primary Purpose: TreatmentStudy ID Numbers: UHN REB 08-0106-CStudy First Received: November 21, 2008Last Updated: August 30, 2016Estimated Primary Completion Date: July 2017Primary Outcome Measures:The primary outcome for the study will be the proportion of patients treated as per protocol without treatment related mortality.|To evaluate: acute and late morbidity related to treatment; local & distant recurrence, disease free & overall survival; identify factors/parameters associated with increased risk of treatment morbiditySponsors and Collaborators:University Health Network, TorontoResult Received: No...

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A Randomised Phase II Open-label Study With a Phase Ib Safety lead-in Cohort of ONCOS-102, an Immune-priming GM-CSF Coding Oncolytic Adenovirus, and Pemetrexed/Cisplatin in Patients With Unresectable Malignant Pleural Mesothelioma

ConditionTo Determine Safety, Tolerability and Efficacy of ONCOS-102 in Combination With ChemotherapyEstimated Enrollment: 30Age Group: 18 Years and older   (Adult, Senior)Gender: AllStudy Type: InterventionalStudy Design Allocation: Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: No masking|Primary Purpose: TreatmentStudy ID Numbers: ONCOS C719|2015-005143-13Study First Received: July 13, 2016Last Updated: February 9, 2017Estimated Primary Completion Date: December 2018Primary Outcome Measures:Number of patients with any (Serious and Non-Serious) Adverse Event measured to assess safety and tolerability|To determine and compare tumour-specific immunological activation in the peripheral blood in the experimental group and the control group. Number of patients in the respective arms with induction of Tumor...

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Tissue Procurement for Gastric Cancer, Gastrointestinal Stromal Tumors (GIST), Esophageal Cancer, Pancreas Cancer, Hepatocellular Cancer, Biliary Cancer, Neuroendocrine, Peritoneal Mesothelioma, Anal Cancer and Colorectal Cancer in Patients Undergoing Surgery or Biopsy

ConditionGastric CancersEstimated Enrollment: 1000Age Group: Child, Adult, SeniorGender: AllStudy Type: ObservationalStudy Design Allocation: Observational Model: Cohort|Time Perspective: ProspectiveStudy ID Numbers: 16294AStudy First Received: August 20, 2010Last Updated: July 20, 2016Estimated Primary Completion Date: October 2017Primary Outcome Measures:Collect and store blood samples|create a database for the collected tissue|To create tissue microarrays for each gastrointestinal cancer subtypeSponsors and Collaborators:University of ChicagoResult Received: No Study Results PostedWebsite Link: https://ClinicalTrials.gov/show/NCT01416714...

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Staging Procedures to Diagnose Malignant Pleural Mesothelioma

ConditionMesothelioma|Solitary Fibrous Tumor of the PleuraEstimated Enrollment: 200Age Group: 18 Years and older   (Adult, Senior)Gender: AllStudy Type: ObservationalStudy Design Allocation: Observational Model: Case-Only|Time Perspective: ProspectiveStudy ID Numbers: 15-007647Study First Received: November 20, 2015Last Updated: December 19, 2016Estimated Primary Completion Date: December 2018Primary Outcome Measures:Accuracy of surgical staging versus imaging procedures based on surgical findings.Sponsors and Collaborators:Mayo ClinicResult Received: No Study Results PostedWebsite Link: https://ClinicalTrials.gov/show/NCT02648763...

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Surgery for Mesothelioma After Radiation Therapy “SMART” for Resectable Malignant Pleural Mesothelioma

ConditionMesothelioma|Solitary Fibrous Tumor of the PleuraEstimated Enrollment: 200Age Group: 18 Years and older   (Adult, Senior)Gender: AllStudy Type: ObservationalStudy Design Allocation: Observational Model: Case-Only|Time Perspective: ProspectiveStudy ID Numbers: 15-007644Study First Received: November 20, 2015Last Updated: December 19, 2016Estimated Primary Completion Date: December 2018Primary Outcome Measures:Survival status upon review of patient records every 6 monthsSponsors and Collaborators:Mayo ClinicResult Received: No Study Results PostedWebsite Link: https://ClinicalTrials.gov/show/NCT02613299...

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Chemotherapy Followed by Surgery and Neoadjuvant Hemothoracic Intensity Modified Radiation Therapy (IMRT) for Patients With Malignant Pleural Mesothelioma

ConditionMesothelioma|Solitary Fibrous Tumor of the PleuraEstimated Enrollment: 200Age Group: 18 Years and older   (Adult, Senior)Gender: AllStudy Type: ObservationalStudy Design Allocation: Observational Model: Case-Only|Time Perspective: ProspectiveStudy ID Numbers: 15-007645Study First Received: November 20, 2015Last Updated: December 19, 2016Estimated Primary Completion Date: December 2018Primary Outcome Measures:Survival status upon review of patients every 6 months|Progression free survival as evidenced by CT scan reviewSponsors and Collaborators:Mayo ClinicResult Received: No Study Results PostedWebsite Link: https://ClinicalTrials.gov/show/NCT02613312...

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